Light-controlled relaxation of the rat penile corpus cavernosum using NOBL-1, a novel nitric oxide releaser
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چکیده
منابع مشابه
Light-controlled relaxation of the rat penile corpus cavernosum using NOBL-1, a novel nitric oxide releaser
PURPOSE To investigate whether relaxation of the rat penile corpus cavernosum could be controlled with NOBL-1, a novel, light-controllable nitric oxide (NO) releaser. MATERIALS AND METHODS Fifteen-week-old male Wistar-ST rats were used. The penile corpus cavernosum was prepared and used in an isometric tension study. After noradrenaline (10(-5) M) achieved precontraction, the penile corpus ca...
متن کاملA Nitric Oxide-like Factor Mediates Nonadrenergic-Nonci Relaxation of Penile Corpus Cavernosum Smooth Muscle
This study was initiated to characterize nonadrenergic-noncholinergic (NANC) inhibitory neurotransmission in penile corpus cavernosum. Using organ baths, isometric tension measurements were made in strips ofhuman and rabbit corpus cavernosum. In examining endothelium-mediated responses, cumulative additions of exogenous acetylcholine elicited dose-dependent relaxations which were significantly ...
متن کاملLeptin Enhances Nitric Oxide-Dependent Relaxation of the Clitoral Corpus Cavernosum
PURPOSE The effects of leptin on female sexual behaviors are controversial, and studies on this topic are limited. The objectives of this study were to evaluate the direct effects of leptin on clitoral vasoreactivity in vitro and to determine the mechanism of action. MATERIALS AND METHODS Isometric tension studies were conducted to determine the effects of pretreatment with leptin (10(-8) M) ...
متن کاملاثر سیروز صفراوی بر پاسخ‌های شل‌شدگی القاء شده با تحریک الکتریکی اعصاب غیرآدرنرژیک غیرکولینرژیک در کورپوس کاورنوزوم موش‌های صحرایی: نقش مسیر نیتریک‌اکساید و کانابینوئیدهای اندوژن
Background: Relaxation of the corpus cavernosum plays a major role in penile erection. Nitric oxide (NO) is known to be the most important factor mediating relaxation of corpus cavernosum, which is mainly derived from nonadrenergic noncholinergic (NANC) nerves. The aim of the present study was to investigate the effect of biliary cirrhosis on nonadrenergic noncholinergic (NANC)-mediated relaxat...
متن کاملPenile erection requires association of soluble guanylyl cyclase with endothelial caveolin-1 in rat corpus cavernosum.
Erectile dysfunction is caused by a variety of pathogenic factors, particularly impaired formation and action of nitric oxide (NO). NO released from nerve endings and corpus cavernosum endothelial cells plays a crucial role in initiating and maintaining increased intracavernous pressure, penile vasodilatation, and penile erection. Classically, these effects are dependent on cGMP synthesized dur...
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ژورنال
عنوان ژورنال: Investigative and Clinical Urology
سال: 2016
ISSN: 2466-0493,2466-054X
DOI: 10.4111/icu.2016.57.3.215